I read the following sentences in a medical paper:
“These cells were used to derive S1 cells that have a number of mutations, but when injected into NOD/SCID mice are nonmalignant; when cultured in 3D, laminin-rich basement membrane gels that recapitulate the normal niche, they ‘growth-arrest’ and form structural mimics of mammary acini found in vivo.
“These cells form nonpolarized, disorganized masses in 3D cultures that do not ‘growth-arrest’.
I don’t get what ‘growth-arrest’ means. Can anybody help me?